MICA polymorphism identified by whole genome array associated with NKG2D-mediated cytotoxicity in T-cell large granular lymphocyte leukemia

  • Viny A
  • Clemente M
  • Jasek M
 et al. 
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Abstract

Large granular lymphocyte leukemia is a semi-autonomous clonal proliferation of cytotoxic T cells accompanied by immune cytopenias and various autoimmune conditions. Due to the rarity of this disease and its association with autoimmune diseases, a theoretical germline or somatic mutation might have significant penetrance, thus enabling detection, even from samples of suboptimal size, through genome-wide association studies.

Author-supplied keywords

  • GWAS
  • Genome-wide association study
  • LGL
  • MICA
  • Neutropenia
  • SNP

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Authors

  • Aaron D. Viny

  • Michael J. Clemente

  • Monika Jasek

  • Medhat Askar

  • Hemant Ishwaran

  • Amy Nowacki

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