Concentration gradients play an important role in controlling biological and pathological processes, such as metastasis, embryogenesis, axon guidance, and wound healing. Microfluidic devices fabricated by photo- and soft lithography techniques can manipulate the fluidic flow and diffusion profile to create biomolecular gradients in a temporal and spatial manner. Furthermore, microfluidic devices enable the control of cell-extracellular microenvironment interactions, including cell-cell, cell-matrix, and cell-soluble factor interaction. In this paper, we review the development of microfluidic-based gradient devices and highlight their biological applications. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
CITATION STYLE
Chung, B. G., & Choo, J. (2010). Microfluidic gradient platforms for controlling cellular behavior. Electrophoresis. Wiley-VCH Verlag. https://doi.org/10.1002/elps.201000137
Mendeley helps you to discover research relevant for your work.