Modulation of the cytosolic and phagosomal pH by the NADPH oxidase.

  • Jankowski A
  • Grinstein S
  • 12


    Mendeley users who have this article in their library.
  • 19


    Citations of this article.


Proton (equivalents) are primary participants in the control and potency of the NADPH oxidase. Both the cytosolic and intraphagosomal pH are influenced during oxidase activation, and maintenance of the optimal environment requires the coordinated action of a series of sophisticated, highly regulated H(+) transporters, including the Na(+)/H(+) exchange, vacuolar H(+)-ATPase, and H(+)-conductive pathway(s). In addition, protons that are produced during some of the NADPH oxidase reactions then are substrates for the dismutation of superoxide, which precedes production of additional bactericidal agents. In this review, pH homeostasis is shown in conjunction with the NADPH oxidase to present an integrated picture of leukocyte physiology during the phagocytic response.

Author-supplied keywords

  • Animals
  • Biological
  • Chemical
  • Cytosol
  • Cytosol: enzymology
  • Humans
  • Hydrogen-Ion Concentration
  • Leukocytes
  • Leukocytes: enzymology
  • Models
  • NADPH Oxidase
  • NADPH Oxidase: metabolism
  • Phagosomes
  • Phagosomes: enzymology
  • Protons

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Andrzej Jankowski

  • Sergio Grinstein

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free