Molecular regulation of neuronal migration during neocortical development

  • Huang Z
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Abstract

Neocortex, a distinct six-layered neural structure, is one of the most exquisite nerve tissues in the human body. Proper assembly of neocortex requires precise regulation of neuronal migration and abnormalities can result in severe neurological diseases. Three major types of neuronal migration have been implicated in corticogenesis: radial migration of excitatory neuron precursors and tangential migration of interneurons as well as Cajal-Retzius cells. In the past several years, significant progress has been made in understanding how these parallel events are regulated and coordinated during corticogenesis. New insights have been gained into regulation of radial neuron migration by the well-known Reelin signal. New pathways have also been identified that regulate radial as well as tangential migration. Equally important, better understandings have been obtained on the cellular and molecular mechanics of cell migration by both projection neurons and interneurons. These findings have not only enhanced our understanding of normal neuron migration but also revealed insights into the etiologies of several neurological diseases where these processes go awry. (C) 2009 Elsevier Inc. All rights reserved

Author-supplied keywords

  • BENIGN HEREDITARY CHOREA
  • BODIES
  • BODY
  • CAJAL-RETZIUS
  • CELL
  • CELL-MIGRATION
  • CONGENITAL MUSCULAR-DYSTROPHIES
  • CORTICAL GABAERGIC INTERNEURONS
  • CXCR4
  • Cajal-Retzius cell
  • Cajal-Retzius cells
  • Cells
  • Chemokine CXCL12
  • Cyclin dependent kinase 5
  • DEVELOPING CEREBRAL-CORTEX
  • DIEKER LISSENCEPHALY GENE
  • DISEASES
  • DOUBLECORTIN-LIKE-KINASE
  • Disease
  • Dlx1/2
  • EVENTS
  • G-protein coupled receptor
  • INSIGHT
  • Neocortex
  • Nerve Tissue
  • Neurological diseases
  • Nkx2-1
  • Notch
  • Nuclear centrosome coupling
  • PATHWAY
  • PATHWAYS
  • PRECURSORS
  • REELIN SIGNALING PATHWAY
  • Radial glia
  • Review
  • Somal translocation
  • TISSUE
  • TISSUES
  • X-linked lissencephaly with abnormal genitalia
  • abnormalities
  • amyloid precursor protein
  • assembly
  • cell migration
  • cerebral cortex
  • corticogenesis
  • development
  • enhanced
  • etiology
  • excitatory
  • human
  • human body
  • interneuron
  • interneurons
  • lissencephaly
  • locomotion
  • mechanics
  • microtubule-associated protein
  • migration
  • neocortical development
  • neural
  • neuregulin
  • neurological
  • neurological disease
  • neuron
  • neuronal
  • neuronal migration
  • neurons
  • precursor
  • projection neuron
  • projection neurons
  • radial
  • radial migration
  • reelin
  • regulation
  • semaphorin
  • signal
  • tangential
  • tangential migration
  • time

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Authors

  • Z Huang

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