Multiminicore disease with respiratory failure

Abstract

Multiminicore disease is a rare form of slowly progressive or nonprogressive myopathy, characterized by multiple cores within the muscle fibers. Respiratory failure in multiminicore disease rarely occurs. We describe a 5-year-old girl with multiminicore disease and early-onset respiratory failure after an episode of bronchopneumonia. The child received mechanical ventilation for 280 days and was discharged on home ventilation. The relevant literature is reviewed. © 2011 Elsevier Inc. All rights reserved.