Multispectral optoacoustic tomography of myocardial infarction

  • Taruttis A
  • Wildgruber M
  • Kosanke K
 et al. 
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Abstract

Objectives: To investigate the feasibility of a high resolution optical imaging strategy for myocardial infarction. Background: Near-infrared approaches to imaging cardiovascular disease enable visualization of disease-associated biological processes in vivo. However, even at the scale of small animals, the strong scattering of light prevents high resolution imaging after the first 1-2. mm of tissue, leading to degraded signal localization. Methods: Multispectral optoacoustic tomography (MSOT) was used to non-invasively image myocardial infarction (MI) in a murine model of coronary artery ligation at resolutions not possible with current deep-tissue optical imaging methods. Post-MI imaging was based on resolving the spectral absorption signature of a dendritic polyglycerol sulfate-based (dPGS) near-infrared imaging agent targeted to P- and L-selectin. Results: In vivo imaging succeeded in detection of the agent in the injured myocardium after intravenous injection. The high anatomic resolution (

Author-supplied keywords

  • Myocardial infarction
  • Optical imaging
  • Optoacoustic imaging

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Authors

  • Adrian Taruttis

  • Moritz Wildgruber

  • Katja Kosanke

  • Nicolas Beziere

  • Kai Licha

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