Nasal CPAP reduces systemic blood pressure in patients with obstructive sleep apnoea and mild sleepiness

  • Hui D
  • To K
  • Ko F
 et al. 
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Abstract

METHODS: Patients were fitted with an ambulatory BP measuring device as outpatients during normal activities and recorded for 24 hours before starting therapeutic or subtherapeutic (4 cm H(2)O) CPAP treatment. BP monitoring was repeated before completion of 12 weeks of treatment. The primary end point was the change in 24 hour mean BP.RESULTS: Twenty three of 28 participants in each treatment arm completed the study. There was no significant difference between the two groups in age, body mass index, Epworth Sleepiness Score, apnoea-hypopnoea index, arousal index, and minimum Sao(2). Twenty four patients were hypertensive. The pressure in the therapeutic CPAP group was 10.7 (0.4) cm H(2)O. CPAP usage was 5.1 (0.4) and 2.6 (0.4) hours/night for the therapeutic and subtherapeutic CPAP groups, respectively (p

Author-supplied keywords

  • Antihypertensive Agents [therapeutic use]
  • Blood Pressure [physiology]
  • Circadian Rhythm
  • Continuous Positive Airway Pressure [methods]
  • Epworth sleepiness scale
  • Female[checkword]
  • Humans[checkword]
  • Hypertension [drug therapy] [physiopathology]
  • Male[checkword]
  • Middle Aged[checkword]
  • Sleep Apnea, Obstructive [complications] [physiopa
  • Sleep Wake Disorders [complications]
  • Sr-airways: sr-htn
  • adult
  • alpha adrenergic receptor blocking agent/cb [Drug
  • alpha adrenergic receptor blocking agent/dt [Drug
  • article
  • beta adrenergic receptor blocking agent/cb [Drug C
  • beta adrenergic receptor blocking agent/dt [Drug T
  • blood pressure monitoring
  • body mass
  • calcium channel blocking agent/cb [Drug Combinatio
  • calcium channel blocking agent/dt [Drug Therapy]
  • clinical trial
  • controlled clinical trial
  • controlled study
  • diastolic blood pressure
  • dipeptidyl carboxypeptidase inhibitor/cb [Drug Com
  • dipeptidyl carboxypeptidase inhibitor/dt [Drug The
  • diuretic agent/cb [Drug Combination]
  • diuretic agent/dt [Drug Therapy]
  • female
  • groups by age
  • human
  • hypertension/dt [Drug Therapy]
  • major clinical study
  • male
  • methyldopa/cb [Drug Combination]
  • methyldopa/dt [Drug Therapy]
  • positive end expiratory pressure
  • priority journal
  • randomized controlled trial
  • sleep apnea syndrome/dt [Drug Therapy]
  • sleep apnea syndrome/th [Therapy]
  • sleep time
  • somnolence
  • treatment duration

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Authors

  • Ds Hui

  • Kw To

  • Fw Ko

  • Jp Fok

  • Mc Chan

  • Jc Ngai

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