Skip to content
Journal article

Neurogenesis in humans

Curtis M, Kam M, Faull R ...see all

European Journal of Neuroscience, vol. 33, issue 6 (2011) pp. 1170-1174

  • 178

    Readers

    Mendeley users who have this article in their library.
  • 50

    Citations

    Citations of this article.
  • N/A

    Views

    ScienceDirect users who have downloaded this article.
Sign in to save reference

Abstract

Since 1944 increasing evidence has been emerging that the adult human brain harbours progenitor cells with the potential to produce neuroblasts. However, it was not until 1998 that this fact was confirmed in the adult human brain. With the purpose of human neurogenesis being hotly debated, many research groups have focussed on the effect of neurodegenerative diseases in the brain to determine the strength of the endogenous regenerative response. Although most of the human studies have focussed on the hippocampus, there is a groundswell of evidence that there is greater plasticity in the subventricular zone and in the ventriculo-olfactory neurogenic system. In this review, we present the evidence for increased or decreased plasticity and neurogenesis in different diseases and with different drug treatments in the adult human brain. Whilst there is a paucity of studies on human neurogenesis, there are sufficient to draw some conclusions about the potential of plasticity in the human brain.

Author-supplied keywords

  • Neurodegnerative disease
  • Plasticity
  • Proliferation
  • Rostral migratory stream
  • Subgranular zone
  • Subventricular zone

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Get full text

Authors

  • Maurice A. Curtis

  • Monica Kam

  • Richard L M Faull

Cite this document

Choose a citation style from the tabs below