Journal article

Neurosedative and muscle relaxant activities of aqueous extract of Bryophyllum pinnatum

Yemitan O, Salahdeen H ...see all

Fitoterapia, vol. 76, issue 2 (2005) pp. 187-193 Published by Elsevier

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Abstract

The saline leaf extract of Bryophyllum pinnatum was investigated on neuropharmacological activities to ascertain claims of local use. When tested in mice, it produced a dose-dependent prolongation of onset and duration of pentobarbitone-induced hypnosis, reduction of exploratory activities in the head-dip and evasion tests. Moreover, a dose-dependent muscle in-coordination was observed in the inclined screen, traction and climbing tests. It delayed onset to convulsion in both strychnine- and picrotoxin-induced seizures in addition to minimal protection against picrotoxin seizures. © 2005 Elsevier B.V. All rights reserved.

Author-supplied keywords

  • Anticonvulsant
  • Bryophyllum pinnatum
  • Muscle relaxant

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Authors

  • O. K. Yemitan

  • H. M. Salahdeen

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