A New 18F-Labeled Folic Acid Derivative with Improved Properties for the PET Imaging of Folate Receptor-Positive Tumors

  • Ross T
  • Honer M
  • Muller C
 et al. 
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Abstract

The folate receptor is a proven target for folate-based diagnosis and treatment of cancer. Several folic acid conjugates have been developed as radiopharmaceuticals, but a suitable (18)F-labeled folic acid derivative for routine clinical use is still lacking. The purpose of this study was to investigate the potential of 2'-(18)F-fluorofolic acid as a PET agent for folate receptor-positive tumors.

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Authors

  • T. L. Ross

  • M. Honer

  • C. Muller

  • V. Groehn

  • R. Schibli

  • S. M. Ametamey

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