A new genetic abnormality leading to TP53 gene deletion in chronic lymphocytic leukaemia

  • López C
  • Baumann T
  • Costa D
 et al. 
  • 11


    Mendeley users who have this article in their library.
  • 5


    Citations of this article.


The analysis of chromosomal abnormalities provides significant prognostic information in patients with chronic lymphocytic leukaemia (CLL), a disease with a highly heterogeneous clinical course. Chromosomal abnormalities commonly found are trisomy 12, del(13)(q14), del(11)(q22-23), del(17)(p13) and del(6)(q21). Translocations are present in some patients and affect regions recurrently involved in CLL. This report describes the clinical and pathological characteristics of four CLL patients showing a new recurrent chromosomal abnormality dic(8;17)(p11;p11), that implied loss of the TP53 gene in all cases. In addition, TP53 gene was mutated in three out of four patients. Mechanically, Low Copy Repeats (LCR) in 17p12 and 8p11 may explain the origin of the translocation by non-allelic homologous recombination (NAHR). Isolated dic(8;17)(p11;p11) in patients with mutated IGHV genes status may not have the same prognostic impact as other mutations or deletions affecting the TP53 gene. Larger series are needed to better evaluate the clinical impact of this chromosomal aberration during the course of the disease.

Author-supplied keywords

  • Chronic lymphocytic leukaemia
  • Dic(8;17)(p11;p11)
  • Recurrent chromosomal abnormality
  • TP53 gene
  • Unbalanced translocation

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Cristina López

  • Tycho Baumann

  • Dolors Costa

  • Mónica López-Guerra

  • Alba Navarro

  • Cándida Gómez

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free