A new HTLV-III/LAV encoded antigen detected by antibodies from AIDS patients

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Abstract

A newly identified protein from HTLV-III/LAV, the virus implicated as the etiologic agent of the acquired immune deficiency syndrome, was studied. This protein, which has a molecular weight of 27,000 (p27), was shown by amino acid sequencing to have a coding origin 3′ to the env gene on the HTLV-III genome. The presence of antibodies to p27 in virus-exposed individuals indicated that this gene is functional in the natural host.

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Allan, J. S., Coligan, J. E., Lee, T. H., Mclane, M. F., Kanki, P. J., Groopman, J. E., & Essex, M. (1985). A new HTLV-III/LAV encoded antigen detected by antibodies from AIDS patients. Science, 230(4727), 810–813. https://doi.org/10.1126/science.2997921

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