A new HTLV-III/LAV encoded antigen detected by antibodies from AIDS patients

  • Allan J
  • Coligan J
  • Lee T
 et al. 
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Abstract

A newly identified protein from HTLV-III/LAV, the virus implicated as the etiologic agent of the acquired immune deficiency syndrome, was studied. This protein, which has a molecular weight of 27,000 (p27), was shown by amino acid sequencing to have a coding origin 3' to the env gene on the HTLV-III genome. The presence of antibodies to p27 in virus-exposed individuals indicated that this gene is functional in the natural host.

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Authors

  • Jonathan S. Allan

  • John E. Coligan

  • Tun Hou Lee

  • Mary Frances Mclane

  • Phyllis J. Kanki

  • Jerome E. Groopman

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