The new mouse genetics: Altering the genome by gene targeting

  • Capecchi M
  • 116

    Readers

    Mendeley users who have this article in their library.
  • 390

    Citations

    Citations of this article.

Abstract

Gene targeting (homologous recombination between DNA sequences residing in the chromosome and newly introduced DNA sequences) in pluripotent, mouse embryo-derived stem (ES) cells promises to provide the means to generate mice of any desired genotype. This review describes some of the background and current advances of gene targeting in mouse ES cells. © 1989.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Mario R. Capecchi

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free