NMR crystallography is an emerging method for atomic-resolution structural analysis of ubiquitous vanadium(V) sites in inorganic and bioinorganic complexes as well as vanadium-containing proteins. NMR crystallography allows for characterization of vanadium(V) containing solids, based on the simultaneous measurement of 51 V- 15 N internuclear distances and anisotropic spin interactions, described by 13 C, 15 N, and 51 V chemical shift anisotropy and 51 V electric field gradient tensors. We show that the experimental 51 V, 13 C, and 15 N NMR parameters are essential for inferring correct coordination numbers and deriving correct geometries in density functional theory (DFT) calculations, particularly in the absence of single-crystal X-ray structures. We first validate this approach on a structurally known vanadium(V) complex, ( 15 N-salicylideneglycinate)-(benzhydroxamate)oxovanadium(V), VO 15 NGlySalbz. We then apply this approach to derive the three-dimensional structure of (methoxo)( 15 N-salicylidene-glycinato)oxovanadium(V) with solvated methanol, [VO( 15 NGlySal)(OCH 3)]·(CH 3 OH). This is a representative complex with potentially variable coordination geometry depending on the solvation level of the solid. The solid material containing molecules of CH 3 OH, formally expressed as [VO( 15 NGlySal)(OCH 3)]·(CH 3 OH), is found to have one molecule of CH 3 OH weakly coordinated to the vanadium. The material is therefore best described as [VO( 15 NGlySal)(OCH 3)(CH 3 OH)] as deduced by the combination of multinuclear solid-state NMR experiments and DFT calculations. The approach reported here can be used for structural analysis of systems that are not amenable to single-crystal X-ray diffraction characterization and which can contain weakly associated solvents.
CITATION STYLE
Li, M., Yehl, J., Hou, G., Chatterjee, P. B., Goldbourt, A., Crans, D. C., & Polenova, T. (2015). NMR crystallography for structural characterization of oxovanadium(V) complexes: Deriving coordination geometry and detecting weakly coordinated ligands at atomic resolution in the solid state. Inorganic Chemistry, 54(4), 1363–1374. https://doi.org/10.1021/ic5022388
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