From the roots of Salvia multicaulis, four new aromatic norditerpenoids, multicaulin (1), 12-demethylmulticauline (2), multiorthoquinone (3) and 12- demethylmultiorthoquinone (4), two new abietane diterpenoids, 12-methyl-5- dehydrohorminone (5) and 12-methyl-5-dehydroacetylhorminone (6), as well as a new pimarane diterpenoid, salvipimarone (7), were isolated. Also obtained in this investigation were the known compounds α-amyrin, hinokione, horminone, lupeol, manool, 1-oxoferruginol, 18-oxoferruginol, pisiferal, and sempervirol. The structures of compounds 1-7 were established by 1D and 2D NMR techniques and by chemical methods. The antituberculous activity of 1-7 was tested against Mycobacterium tuberculosis strain H37Rv, and all compounds were found to be significantly active, with 2 and 4-6 being the most potent substances. Six of these novel compounds were evaluated against a number of additional bacterial cultures.
CITATION STYLE
Ulubelen, A., Topcu, G., & Johansson, C. B. (1997). Norditerpenoids and diterpenoids from Salvia multicaulis with antituberculous activity. Journal of Natural Products, 60(12), 1275–1280. https://doi.org/10.1021/np9700681
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