Journal article

Normal Tissue Tolerance Dose Metrics for Radiation Therapy of Major Organs

Milano M, Constine L, Okunieff P ...see all

Seminars in Radiation Oncology, vol. 17, issue 2 (2007) pp. 131-140

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Abstract

Late organ toxicity from therapeutic radiation is a function of many confounding variables. The total dose delivered to the organ and the volumes of organ exposed to a given dose of radiation are 2 important variables that can be used to predict the risk of late toxicity. Three-dimensional radiation planning enables accurate calculation of the volume of tissue exposed to a given dose of radiation, graphically depicted as a dose-volume histogram. Dose metrics obtained from this 3-dimensional dataset can be used as a quantitative measure to predict late toxicity. This review summarizes the published clinical data on the risk of late toxicity as a function of quantitative dose metrics and attempts to offer suggested dose constraints for radiation treatment planning. © 2007 Elsevier Inc. All rights reserved.

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Authors

  • Michael T. Milano

  • Louis S. Constine

  • Paul Okunieff

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