One-state models: simple agonism and ant-agonism

  • Models O
  • Agonismant-agonism S
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Part I is on one-state models. The various concepts of ligand-receptor interaction were first developed during a so-called classic era ending in 1945, and then during a post-classic era , starting in 1965, with what could be called a transition period between 1945 and 1965. Concepts from the classic era were mostly concerned with occupancy or function as a two-step and one-state mechanism, while the post-classic era was and is preoccupied with states of conformational changes for un-liganded receptive units, a two-state mechanism. To have a single-word indicator for dose-response effects at equilibrium , the term “synagics” is introduced. Citation: Bindslev N 2008. DOI: 10.3402/bindslev.2008.2

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  • One-state Models

  • Simple Agonismant-agonism

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