Opioid receptor polymorphisms and opioid abuse

  • Lee N
  • Smith A
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The sequencing of the human genome is only the first step. The next step is to determine the function of these genes and in particular, how alterations in specific genes lead to major human disorders. Many laboratories are now focusing on identifying and characterizing single nucleotide polymorphisms (SNPs), to determine which correlate in frequency with certain population groups who may be particularly susceptible to certain diseases. The μ opioid receptor (MOR), which mediates the clinically important analgesic effects of drugs like morphine as well as the euphoria sought by heroin abusers, exhibits several dozen polymorphisms. Several of these are associated with altered receptor function and individuals at risk for drug abuse.

Author-supplied keywords

  • Analgesia
  • Animals
  • Drug abuse
  • G-protein-coupled receptor
  • Humans
  • Morphine
  • Opioid tolerance
  • Opioid-Related Disorders
  • Polymorphism, Genetic
  • Receptors, Opioid
  • SNP
  • Signal transduction
  • alcohol
  • alcohol abuse
  • analgesic activity
  • cocaine
  • cocaine dependence
  • correlation analysis
  • delta opiate receptor
  • diamorphine
  • disease association
  • disease predisposition
  • euphoria
  • gene frequency
  • gene function
  • gene mutation
  • gene sequence
  • gene structure
  • genetic polymorphism
  • heroin dependence
  • human
  • kappa opiate receptor
  • laboratory test
  • mu opiate receptor
  • opiate
  • opiate addiction
  • opiate receptor
  • pharmacogenomics
  • population research
  • review
  • risk assessment
  • single nucleotide polymorphism
  • μ opioid receptor

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  • N M Lee

  • A P Smith

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