The orphan adhesion-GPCR GPR126 is required for embryonic development in the mouse

  • Waller-Evans H
  • Prömel S
  • Langenhan T
 et al. 
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Abstract

Adhesion-GPCRs provide essential cell-cell and cell-matrix interactions in development, and have been implicated in inherited human diseases like Usher Syndrome and bilateral frontoparietal polymicrogyria. They are the second largest subfamily of seven-transmembrane spanning proteins in vertebrates, but the function of most of these receptors is still not understood. The orphan Adhesion-GPCR GPR126 has recently been shown to play an essential role in the myelination of peripheral nerves in zebrafish. In parallel, whole-genome association studies have implicated variation at the GPR126 locus as a determinant of body height in the human population. The physiological function of GPR126 in mammals is still unknown. We describe a targeted mutation of GPR126 in the mouse, and show that GPR126 is required for embryonic viability and cardiovascular development.

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Authors

  • William ColledgeUniversity of Cambridge

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  • Helen Waller-Evans

  • Simone Prömel

  • Tobias Langenhan

  • John Dixon

  • Dirk Zahn

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