Outcome after pancreatectomy and islet autotransplantation in a pediatric population

  • Bellin M
  • Carlson A
  • Kobayashi T
 et al. 
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Abstract

OBJECTIVES: Little is known regarding outcomes after pancreatectomy and islet autotransplantation for chronic pancreatitis in pediatric patients. In this study, we document pain control and metabolic course after this procedure in a pediatric population. MATERIALS AND METHODS: We reviewed medical records for 24 patients 18 years old or younger who underwent pancreatectomy with islet autotransplantation at the University of Minnesota from July 1989 through June 2006. Patients and/or their parents were invited to participate in a follow-up telephone survey. Primary outcome measures were narcotics and insulin use at follow-up. We compared outcomes in patients undergoing surgery as preadolescents (2000 islet equivalents per kilogram and lack of prior pancreatic surgery (P = 0.011). Preadolescents were less likely to require chronic narcotic therapy at follow-up (P = 0.05) and were more likely to maintain graft function (P = 0.02) compared with adolescents. CONCLUSIONS: Pancreatectomy can relieve pain in pediatric patients with chronic pancreatitis and the majority can withdraw from narcotics. Islet autotransplantation can prevent or reduce the severity of diabetes in about three fourths of patients. Outcome goals were reached in a higher proportion of younger than older children.

Author-supplied keywords

  • Autologous islet cell transplant
  • Chronic pancreatitis
  • Islet autotransplant
  • Pancreatectomy

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Authors

  • Melena D. Bellin

  • Annelisa M. Carlson

  • Takashi Kobayashi

  • Angelika C. Gruessner

  • Bernhard J. Hering

  • Antoinette Moran

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