P50 sensory gating and smoking in the general population

  • Brinkmeyer J
  • Mobascher A
  • Musso F
 et al. 
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Abstract

P50 gating is a major functional biomarker in research on schizophrenia and other psychiatric conditions with high smoking prevalence. It is used as endophenotype for studying nicotinic systems genetics and as surrogate endpoint measure for drug development of nicotinic agonists. Surprisingly, little is known about P50 gating in the general population and the relationship to smoking-related characteristics. In this multicenter study at six academic institutions throughout Germany, n=907 never-smokers (NS

Author-supplied keywords

  • General population
  • LORETA
  • Normative sample data
  • P50 gating
  • Smoking
  • Time-frequency

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Authors

  • Jürgen Brinkmeyer

  • Arian Mobascher

  • Francesco Musso

  • Melanie Schmitz

  • Michael Wagner

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