Palladium asymmetric allylic alkylation of prochiral nucleophiles: Horsfiline

  • Trost B
  • Brennan M
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Abstract

[reaction; see text] The asymmetric synthesis of the oxindole alkaloid horsfiline is described. A palladium-catalyzed asymmetric allylic alkylation (AAA) is used to set the spiro(pyrrolidine-oxindole) stereogenic center.

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Authors

  • Barry M. Trost

  • Megan K. Brennan

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