Palladium asymmetric allylic alkylation of prochiral nucleophiles: Horsfiline

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Abstract

The asymmetric synthesis of the oxindole alkaloid horsfiline is described. A palladium-catalyzed asymmetric allylic alkylation (AAA) is used to set the spiro(pyrrolidine-oxindole) stereogenic center. © 2006 American Chemical Society.

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Trost, B. M., & Brennan, M. K. (2006). Palladium asymmetric allylic alkylation of prochiral nucleophiles: Horsfiline. Organic Letters, 8(10), 2027–2030. https://doi.org/10.1021/ol060298j

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