Paracoccidioidomycosis: An epidemiologic survey in a pediatric population from the Brazilian Amazon using skin tests

  • E.M.N. K
  • F.E.C. A
  • F.P. A
 et al. 
  • 1


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


Since Paracoccidioides brasiliensis and Histoplasma capsulatum are known to be present in similar environments, there have been many epidemiologic investigations regarding the prevalences of these two organisms. However, cross-reactivity can occur in paracoccidioidin and histoplasmin skin tests, and this usually results in the overestimation of the prevalence of P. brasiliensis. The prevalence of infection with P. brasiliensis was evaluated in a cross-sectional study of 298 asymptomatic school children in the Brazilian Amazon region (Mato Grosso State). In this investigation, the reactivity of children to two different P. brasiliensis antigen preparations, paracoccidioidin and a purified 43-kD glycoprotein (gp43), was compared with or without the co-administration of histoplasmin. In the group of individuals receiving paracoccidioidin who had a positive histoplasmin skin test result, the prevalence of exposure to P. brasiliensis was 44% (16 of 36). This reactivity to P. brasiliensis was significantly higher than that observed in other groups, which ranged from 4% to 6% (P < 5 x 10(-4) for each). Overall prevalence was 4.6% (95% confidence interval = 2.5-7.7%). These data suggest that gp43 provides a better estimate of exposure to P. brasiliensis when the co-administration of histoplasmin is desired.

Author-supplied keywords

  • *Antigens
  • *Brazil
  • *Fungal Proteins
  • *Glycosaminoglycans/an [Analysis]
  • *Histoplasmin/an [Analysis]
  • *Paracoccidioides/im [Immunology]
  • *Paracoccidioidomycosis/ep [Epidemiology]
  • *South American blastomycosis/di [Diagnosis]
  • *South American blastomycosis/ep [Epidemiology]
  • *South American blastomycosis/et [Etiology]
  • *histoplasmin
  • *paracoccidioidin
  • *parasite antigen
  • *skin test
  • Adolescent
  • Brazil/ep [Epidemiology]
  • Child
  • Female
  • Fungal Proteins/im [Immunology]
  • Fungal/an [Analysis]
  • Glycoproteins/im [Immunology]
  • Glycosaminoglycans/im [Immunology]
  • Histoplasma capsulatum
  • Histoplasmin/im [Immunology]
  • Humans
  • Intradermal Tests
  • Male
  • Paracoccidioides brasiliensis
  • Paracoccidioidomycosis/di [Diagnosis]
  • Paracoccidioidomycosis/im [Immunology]
  • Prevalence
  • Skin Tests
  • article
  • cross reaction
  • female
  • human
  • major clinical study
  • male
  • prevalence
  • risk factor
  • school child
  • statistical analysis
  • unclassified drug

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Kalmar E.M.N.

  • Alencar F.E.C.

  • Alves F.P.

  • Pang L.W.

  • Del Negro G.M.B.

  • Camargo Z.P.

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free