PD-L1 Expression in Non-clear cell Renal Cell Carcinoma

  • Choueiri T
  • Fay A
  • Gray K
 et al. 
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BACKGROUND: Program Death Ligand-1 (PD-L1) expression in non-clear cell RCC (non-ccRCC) and its association with clinical outcomes are unknown. METHODS: Formalin-fixed paraffin-embedded (FFPE) specimens were obtained from 101 patients with non-ccRCC. PD-L1 expression was evaluated by immunohistochemistry in both tumor cell membrane and tumor infiltrating mononuclear cells (TIMC). PD-L1 tumor positivity was defined as >/=5% tumor cell membrane staining. For PD-L1 expression in TIMC, a combined score based on the extent of infiltrate and percentage of positive cells was used. Baseline clinico-pathological characteristics and outcome data [time to recurrence (TTR) and survival (OS)] were correlated with PD-L1 staining. RESULTS: Among 101 patients, 11 (10.9%) were considered PD-L1+ in tumor cells: 2/36 (5.6%) of chromophobe RCC, 5/50 (10%) of papillary RCC, 3/10 (30%) of Xp11.2 translocation RCC and 1/5 (20%) of collecting duct carcinoma. PD-L1 positivity (PD-L1+) in tumor cells was significantly associated with higher stage (p=0.01) and grade (p=0.03), as well as shorter OS (p

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  • T K Choueiri

  • A P Fay

  • K P Gray

  • M Callea

  • T H Ho

  • L Albiges

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