Pharmacokinetics of aditoprim and trimethoprim in buffalo calves

Abstract

Pharmacokinetic parameters of two antifolates, trimethoprim and aditoprim, were studied in buffalo calves. The elimination half‐life of aditoprim (6.14 h) was nearly twice as long as that of trimethoprim (3.08 h) and compares well with values observed in heifers. This longer half‐life of aditoprim is a result of its much larger distribution volume (four to five times larger) because the clearance of aditoprim was about twice as high as that of trimethoprim. The longer half‐life of aditoprim is expected to give a longer duration of in vivo bacteriostatic activity than that of trimethoprim. Copyright © 1994 John Wiley & Sons, Ltd.