Phenotypic differences in children conceived from fresh and thawed embryos in in vitro fertilization compared with naturally conceived children

  • Green M
  • Mouat F
  • Miles H
 et al. 
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Objective: To determine whether anthropometric and biochemical features differ in in vitro fertilization (IVF) children conceived via fresh (IVFF) or thawed (IVFT) embryo transfer compared with naturally conceived controls. Design: A cross-sectional controlled study. Setting: University clinical research unit. Patient(s): Healthy prepubertal children (3.5-11.0 years), singletons, born at term (>37 weeks), who were either naturally conceived (controls; n = 94) or IVF children conceived via the transfer of a fresh (IVFF; n = 72) or thawed (IVFT; n = 43) embryo. Intervention(s): None. Main Outcome Measure(s): Assessments of anthropometry (adjusted for parental variables), dual-energy X-ray absorptiometry-derived body composition, fasting plasma growth factors, lipids, and parameters of glucose regulation. Result(s): The IVFFbut not the IVFTchildren weighed less at birth than the control children. The IVFFchildren were taller than both the controls and IVFTchildren. Sex-specific analyses showed height differences among girls, with IVFFgirls being taller than their control and IVFTcounterparts. Taller stature in IVFFchildren was associated with increased insulin-like growth factor I (IGF-I) concentrations compared with controls, whereas the IVFTchildren displayed increased IGF-II and decreased insulin-like growth factor binding protein 3 (IGFBP-3) concentrations compared with the controls. More favorable lipid profiles were also evident in IVFFbut not IVFTchildren compared with the control children. Conclusion(s): These preliminary findings highlight that the transfer of a fresh versus a thawed IVF embryo affects height, plasma growth factor, and lipid profiles in childhood. Therefore, embryo derivation should be considered when assessing physical and biochemical phenotype of IVF children. © 2013 American Society for Reproductive Medicine, Published by Elsevier Inc.

Author-supplied keywords

  • BMI
  • IGF
  • IVF
  • child
  • growth

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  • Mark P. Green

  • Fran Mouat

  • Harriet L. Miles

  • Sarah A. Hopkins

  • José G B Derraik

  • Paul L. Hofman

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