Phosphine-based redox catalysis in the direct traceless staudinger ligation of carboxylic acids and azides

  • Kosal A
  • Wilson E
  • Ashfeld B
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Abstract

Redox catalysis: Aryl amides, imides, lactams, and dipeptides are obtained through a direct Staudinger ligation mediated by phosphine-based redox catalysis. Mechanistic studies indicate the involvement of a phosphonium carboxylate intermediate that leads to a 1,3-acyl migration and thus results in CN bond formation.

Author-supplied keywords

  • Staudinger ligation
  • amides
  • azides
  • carboxylic acids
  • homogeneous catalysis

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Authors

  • Andrew D. Kosal

  • Erin E. Wilson

  • Brandon L. Ashfeld

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