PKC and CaMKII dependent synaptic potentiation in cultured cerebral neurons

  • Kudoh S
  • Nagai R
  • Kiyosue K
 et al. 
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Abstract

We have reported that the long-lasting potentiation of spontaneous excitatory postsynaptic currents (SEPSCs) was induced by a Mg2+-free treatment in cultured chick cerebral neurons and a factor(s) extracellularly released during the treatment could induce the potentiation by itself. In this paper, protein kinase C (PKC) and calcium/calmodulin-dependent protein kinase type II (CaMKII) but not protein kinase A (PKA) were reported to contribute to the potentiation mechanism during a step between the activation of the N-methyl-D-aspartate receptors by the Mg2+-free treatment and the secretion of the protein factor(s). © 2001 Elsevier Science B.V. All rights reserved.

Author-supplied keywords

  • CaMKII
  • Culture system
  • PKC
  • Protein factor
  • Synaptic potentiation

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Authors

  • Suguru N. Kudoh

  • Rina Nagai

  • Kazuyuki Kiyosue

  • Takahisa Taguchi

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