Plasticity of skeletal muscle: Regenerating fibers adapt more rapidly than surviving fibers

  • Donovan C
  • Faulkner J
  • 2

    Readers

    Mendeley users who have this article in their library.
  • 31

    Citations

    Citations of this article.

Abstract

The properties of mammalian skeletal muscle demonstrate a high degree of structural and functional plasticity as evidenced by their adaptability to an atypical site after cross-transplantation and to atypical innervation after cross-innervation. We tested the hypothesis that, regardless of fiber type, skeletal muscles composed of regenerating fibers adapt more readily than muscles composed of surviving fibers when placed in an atypical site with atypical innervation. Fast muscles of rats were autografted into the site of slow muscles or vice versa with the donor muscle innervated by the motor nerve to the recipient site. Surviving fibers in donor muscles were obtained by grafting with vasculature intact (vascularized muscle graft), and regenerating fibers were obtained by grafting with vasculature severed (free muscle graft). Our hypothesis was supported because 60 days after grafting, transposed muscles with surviving fibers demonstrated only a slight change from the contractile properties and fiber typing of donor muscles, whereas transplanted muscles with regenerating fibers demonstrated almost complete change to those of the muscle formerly in the atypical site.

Author-supplied keywords

  • Animals
  • Autologous
  • Female
  • Inbred Strains
  • Muscles
  • Muscles: physiology
  • Muscles: transplantation
  • Rats
  • Regeneration
  • Transplantation

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

  • SCOPUS: 2-s2.0-0023180879
  • PUI: 17093471
  • ISSN: 8750-7587
  • PMID: 3610942
  • SGR: 0023180879

Authors

  • C M Donovan

  • J A Faulkner

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free