Polyclonal proliferation of plasma cells associated with marked hypergammaglobulinemia in an elderly patient.

  • Ohno H
  • Tanaka H
  • Sakai H
 et al. 
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Abstract

We describe an 89-year-old woman who presented with prominent plasmacytosis mimicking plasma cell leukemia. The apparent serum M-protein level of > 7 g/dL of gamma mobility was revealed to be a polyclonal increase of immunoglobulins. The plasma cells in the peripheral blood expressed polyclonal surface/cytoplasmic immunoglobulins as well as CD19, CD30, CD38, and CD138 antigens but lacked CD10, CD20, CD25, and CD56. The bone marrow plasma cells showed the CD45+, CD19+, CD56-, MPC-1(-/+), and CD49e- immunophenotype, which was in clear contrast with the immunophenotypes of the neoplastic myeloma cells. Abdominal lymphadenopathy, splenomegaly, and a high level of soluble interleukin 2 receptor may have been reflections of an underlying lymphoproliferative disorder, potentially leading to the polyclonal proliferation of plasma cells.

Author-supplied keywords

  • cd30
  • flow cytometry
  • immunoelectrophoresis
  • polyclonal hypergammaglobulinemia
  • polyclonal plasmacytosis

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Authors

  • Hitoshi Ohno

  • Hideaki Tanaka

  • Hisashi Sakai

  • Tatsuya Katsurada

  • Yataro Yoshida

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