We describe an 89-year-old woman who presented with prominent plasmacytosis mimicking plasma cell leukemia. The apparent serum M-protein level of >7 g/dL of γ mobility was revealed to be a polyclonal increase of immunoglobulins. The plasma cells in the peripheral blood expressed polyclonal surface/cytoplasmic immunoglobulins as well as CD19, CD30, CD38, and CD138 antigens but lacked CD10, CD20, CD25, and CD56. The bone marrow plasma cells showed the CD45+, CD19+, CD56-, MPC-1 -/+, and CD49e- immunophenotype, which was in clear contrast with the immunophenotypes of the neoplastic myeloma cells. Abdominal lymphadenopathy, splenomegaly, and a high level of soluble interleukin 2 receptor may have been reflections of an underlying lymphoproliferative disorder, potentially leading to the polyclonal proliferation of plasma cells. © 2005 The Japanese Society of Hematology.
CITATION STYLE
Ohno, H., Tanaka, H., Sakai, H., Katsurada, T., & Yoshida, Y. (2005). Polyclonal proliferation of plasma cells associated with marked hypergammaglobulinemia in an elderly patient. International Journal of Hematology, 81(1), 62–65. https://doi.org/10.1532/IJH97.04136
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