Polymorphism of the apolipoprotein E gene and risk of myocardial infarction

  • Mustafina O
  • Shagisultanova E
  • Tuktarova I
 et al. 
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Abstract

The apolipoprotein E (ApoE) gene polymorphism resulting from nucleotide substitutions in exon 4 was analyzed in Russian and Tatar patients with myocardial infarction (MI) from Bashkortostan. Alleles epsilon2, epsilon3, and epsilon4 were identified by PCR. The genotype frequency distribution proved to be age-dependent in healthy Russians, genotype E2/3 increasing in frequency in subjects over 45. Russians who suffered MI under 45 had lower frequencies of genotype E3/3 (50.00% vs. 75.47% in controls of the same age, P = 0.013, OR = 0.33) and allele epsilon3 (72.12% vs. 85.85%, P = 0.020, OR = 0.43) and a higher frequency of allele epsilon4 (22.12% vs. 10.38%, P = 0.030, OR = 2.45). Russians who suffered MI complicated by cardiogenic shock (CS) had a significantly higher frequency of genotype E3/4 and lower frequencies of genotype E3/3 and allele epsilon3 as compared with MI patients without CS. In Tatars, genotype E4/4 occurred at a frequency of 14.29% in patients who suffered MI under 45, and was not detected in healthy subjects of the same age (P = 0.024, OR = 17.85). Thus, the ApoE polymorphism was associated with higher risk of MI in Russians and Tatars under 45.

Author-supplied keywords

  • Apolipoprotein E
  • Coronary heart disease
  • Human genome
  • Myocardial infarction
  • Polymerase chain reaction

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Authors

  • O. E. Mustafina

  • E. I. Shagisultanova

  • I. A. Tuktarova

  • E. K. Khusnutdinova

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