Post-partum weight loss and glucose metabolism in women with gestational diabetes: the DEBI Study.

  • Ehrlich S
  • Hedderson M
  • Quesenberry C
 et al. 
  • 19

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Abstract

AIMS: Women with gestational diabetes are at high risk for developing diabetes; post-partum weight loss may reduce the risk of diabetes. We evaluated the association of post-partum weight change with changes in glucose, insulin and homeostasis model assessment of insulin resistance in a subsample (n = 72) of participants from Diet Exercise and Breastfeeding Intervention (DEBI), a randomized pilot trial of lifestyle intervention for women with gestational diabetes.

METHODS: Glucose and insulin were measured fasting and 2 h after an oral glucose tolerance test at 6 weeks and 12 months post-partum. Women were categorized by weight change (lost > 2 kg vs. maintained/gained) between 6 weeks and 12 months post-partum.

RESULTS: Compared with women who maintained or gained weight, women who lost > 2 kg experienced significantly lower increases in fasting glucose [age-adjusted means: 0.1 mmol/l (95% CI -0.03 to 0.3) vs. 0.4 mmol/l (95% CI 0.3-0.6); P 
CONCLUSIONS: In women with gestational diabetes, modest post-partum weight loss may be associated with improvements in glucose metabolism.

Author-supplied keywords

  • Adult
  • Blood Glucose
  • Blood Glucose: metabolism
  • Breast Feeding
  • Breast Feeding: statistics & numerical data
  • Cross-Over Studies
  • Diabetes Mellitus, Type 2
  • Diabetes Mellitus, Type 2: epidemiology
  • Diabetes Mellitus, Type 2: ethnology
  • Diabetes Mellitus, Type 2: prevention & control
  • Diabetes, Gestational
  • Diabetes, Gestational: epidemiology
  • Diabetes, Gestational: ethnology
  • Diabetes, Gestational: metabolism
  • Educational Status
  • Fasting
  • Female
  • Glucose Tolerance Test
  • Homeostasis
  • Humans
  • Infant
  • Infant, Newborn
  • Patient Education as Topic
  • Pilot Projects
  • Postpartum Period
  • Pregnancy
  • Risk Reduction Behavior
  • United States
  • United States: epidemiology
  • United States: ethnology
  • Weight Gain
  • Weight Loss

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Authors

  • S F Ehrlich

  • M M Hedderson

  • C P Quesenberry

  • J Feng

  • S D Brown

  • Y Crites

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