Precision required for dose-escalated treatment of spinal metastases and implications for image-guided radiation therapy (IGRT)

  • Guckenberger M
  • Meyer J
  • Wilbert J
 et al. 
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Abstract

Introduction: To evaluate the precision required in dose-escalated IMRT treatment of spinal metastases and paraspinal tumors. Methods: In IMRT treatment plans of nine patients with spinal metastases (n = 7) and paraspinal tumors (n = 2) translational patient positioning errors (0-10 mm) and rotational errors (0-7.5°) were simulated. The dose to the spinal cord (D5spine) resulting from these simulations was evaluated and NTCP for spinal cord necrosis was calculated. All patient set-up errors observed during treatment were simulated and the influence on D5spinewas investigated. Results: To keep the dose distribution to the spinal cord within ±5% (±10%) of the prescribed dose, maximum tolerable errors of 1 mm (2 mm) in the transversal plane, 4 mm (7 mm) in superior-inferior direction and maximum rotations of 3.5° (5°) were calculated on average. The translational and rotational component of clinically observed set-up errors increased D5spineby 23 ± 14% and 3 ± 2% on average, respectively. Conclusion: Steep dose gradients of IMRT planning require very high precision. In selected patients correction of both translational and rotational errors may be beneficial. © 2007 Elsevier Ireland Ltd. All rights reserved.

Author-supplied keywords

  • Cone-beam CT
  • Image-guided radiotherapy (IGRT)
  • Intensity-modulated radiotherapy (IMRT)
  • Rotational set-up errors
  • Spinal metastasis

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