Production and purification of glutamic acid: A critical review towards process intensification

  • Kumar R
  • Vikramachakravarthi D
  • Pal P
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Amidst growing environmental awareness and stringent discharge
regulations, chemical and allied process industries are now desperately
seeking replacement of the conventional, polluting processes by clean
and green processes. In this context, production and purification of
amino acids like L-glutamic acid assumes significance. Concerned
conventional process involves several steps like fermentation,
centrifugation, carbon adsorption, evaporation, crystallization,
ion-exchange and so on to get glutamic acid in desired concentration and
purification. Despite its tremendous potential for large scale use in a
wide variety of applications, cost-effective production of high purity
glutamic acid has remained a challenge for decades, mainly due to
several downstream processing steps and the associated cost factors.
With emergence of tailor-made membranes and modules, possibility of
using membranes in downstream purification of glutamic acid appears
imminent with expectation of a turnaround in amino acid manufacturing
industry. The present study through a brief yet comprehensive review of
the very critical aspects of glutamic acid production and purification,
attempts to direct research efforts towards process intensification
encompassing the concepts of green processing, compact and flexible
design with promise of more economically attractive production with
better quality. (C) 2014 Elsevier B.V. All rights reserved.

Author-supplied keywords

  • L-Glutamic acid; Membrane system; Green technology

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  • Ramesh Kumar

  • D Vikramachakravarthi

  • Parimal Pal

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