The Prognostic Role of a Gene Signature from Tumorigenic Breast-Cancer Cells

  • Liu R
  • Wang X
  • Chen G
 et al. 
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Abstract

Background Breast cancers contain a minority population of cancer cells characterized by CD44 expression but low or undetectable levels of CD24 (CD44+CD24−/low) that have higher tumorigenic capacity than other subtypes of cancer cells. Methods We compared the gene-expression profile of CD44+CD24−/low tumorigenic breast-cancer cells with that of normal breast epithelium. Differentially expressed genes were used to generate a 186-gene “invasiveness” gene signature (IGS), which was evaluated for its association with overall survival and metastasis-free survival in patients with breast cancer or other types of cancer. Results There was a significant association between the IGS and both overall and metastasis-free survival (P

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Authors

  • Rui Liu

  • Xinhao Wang

  • Grace Y. Chen

  • Piero Dalerba

  • Austin Gurney

  • Timothy Hoey

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