Prostaglandin D2-DP signaling promotes endothelial barrier function via the cAMP/PKA/Tiam1/Rac1 pathway

  • Kobayashi K
  • Tsubosaka Y
  • Hori M
 et al. 
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Prostaglandin D(2) (PGD(2)) is one of the prostanoids produced during inflammation. Although PGD(2) is known to decrease endothelial permeability through D prostanoid (DP) receptor stimulation, the detailed mechanism is unknown.

Author-supplied keywords

  • endothelial permeability
  • prostaglandin D2

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  • Koji Kobayashi

  • Yoshiki Tsubosaka

  • Masatoshi Hori

  • Shuh Narumiya

  • Hiroshi Ozaki

  • Takahisa Murata

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