Protective functions of intracellular heat-shock protein (HSP) 70-expression in patients with severe sepsis

  • Bruemmer-Smith S
  • Stüber F
  • Schroeder S
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Abstract

Intracellular expression of heat-shock-protein 70 (HSP70) arose early in evolutionary development as a tool to protect cellular homeostasis. HSP70 detects proteins that are incorrectly folded or denatured. They form a complex with such proteins which can lead to correct folding, compartmentalization in organelles, or to proteolytic degradation. HSP70 also appears to protect proteins from degeneration. Intracellular HSP70-expression is induced by a wide variety of stimuli including heat, fever, hypoxia, oxygen radicals, endotoxins, cytokines, and heavy metal ions. Pre-emptive induction of HSP70-expression reduces organ dysfunction and mortality in animal models of sepsis.

Author-supplied keywords

  • Cytokines
  • HSP70
  • Heat-shock-protein 70
  • Intensive care
  • Protective function
  • Sepsis

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Authors

  • S. Bruemmer-Smith

  • F. Stüber

  • S. Schroeder

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