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Journal Article

Psymberin, a potent sponge-derived cytotoxin from Psammocinia distantly related to the pederin family

Organic Letters (2004) 6(12) 1951-1954
DOI: 10.1021/ol049503q
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Abstract

Equation presented. Bioassay-guided fractionation of the sponge Psammocinia sp. afforded psymberin (1) possessing 5S,8S,9S,11R,13R,15S,16R,17R stereochemistry. Psymberin exhibits structural similarities to the pederin family metabolites. The potent cytotoxicty and unique structural features of 1 make it a promising lead for therapeutic development.

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Cichewicz, R. H., Valeriote, F. A., & Crews, P. (2004). Psymberin, a potent sponge-derived cytotoxin from Psammocinia distantly related to the pederin family. Organic Letters, 6(12), 1951–1954. https://doi.org/10.1021/ol049503q

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