PUPylation Provides the Punch As Mycobacterium tuberculosis Battles the Host Macrophage

Abstract

The proteasome machinery has been shown to provide Mycobacterium tuberculosis (Mtb) with the ability to protect itself from the damaging effects of reactive nitrogen intermediates. In their recent paper, Darwin and colleagues identify the protein modifier in Mtb that targets substrates for degradation in the Mtb proteasome. © 2008 Elsevier Inc. All rights reserved.