Rational dosing of antibiotics: The use of plasma concentrations versus tissue concentrations

  • Liu P
  • Müller M
  • Derendorf H
  • 49


    Mendeley users who have this article in their library.
  • 122


    Citations of this article.


At the moment, the most common pharmacokinetic/pharmacodynamic (PK/PD) approaches for anti-infective agents, such as time above MIC, Cmax/MIC and AUC24/MIC, rely on plasma concentration as the PK input value and minimum inhibitory concentration (MIC) as the PD input value. However, only the free tissue concentrations of antibiotics at the target site are responsible for the therapeutic effect. Using plasma concentrations frequently overestimates the target site concentrations and therefore clinical efficacy. Microdialysis is a new technique that allows direct measurement of unbound tissue concentrations. Furthermore, a better PD approach, bacterial time-kill curves, can offer more detailed information about the antibacterial activity as a function of time and antibiotic concentration than MICs. Copyright © 2002 Elsevier Science B.V.

Author-supplied keywords

  • Antibiotics
  • Bacterial kill curve
  • Free tissue concentrations
  • MIC
  • Microdialysis
  • Plasma concentrations

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Ping Liu

  • Markus Müller

  • Hartmut Derendorf

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free