Reduced Accumulation of Specific MicroRNAs in Colorectal Neoplasia11Note: Susan M. O' Connor and Nicholas G. van Holst Pellekaan contributed equally to this work.

  • Michael M
  • Connor S
  • Pellekaan N
 et al. 
  • 45

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Abstract

Short non-coding RNAs are known to regulate cellular processes including development, heterochromatin formation, and genomic stability in eukaryotes. Given the impact of these processes on cellular identity, a study was undertaken to investigate possible changes in microRNA (miRNA) levels during tumorigenesis. A total of 28 different miRNA sequences was identified in a colonic adenocarcinoma and normal mucosa, including 3 novel sequences and a further 7 that had previously been cloned only from mice. Human homologues of murine miRNA sequences, miR-143 and miR-145, consistently display reduced steady-state levels of the mature miRNA at the adenomatous and cancer stages of colorectal neoplasia.

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Authors

  • Michael Z. Michael

  • Susan M. O' Connor

  • Nicholas G. van Holst Pellekaan

  • Graeme P. Young

  • Robert J. James

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