Reduced mortality rate in patients with severe traumatic brain injury treated with brain tissue oxygen monitoring

  • Michael F. Stiefel
  • Alejandro Spiotta
  • Vincent H. Gracias
 et al. 
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Object. An intracranial pressure (ICP) monitor, from which cerebral perfusion pressure (CPP) is estimated, is recommended in the care of severe traumatic brain injury (TBI). Nevertheless, optimal ICP and CPP management may not always prevent cerebral ischemia, which adversely influences patient outcome. The authors therefore determined whether the addition of a brain tissue oxygen tension (PO2) monitor in the treatment of TBI was associated with an improved patient outcome. Methods. Patients with severe TBI (Glasgow Coma Scale [GCS] score < 8) who had been admitted to a Level I trauma center were evaluated as part of a prospective observational database. Patients treated with ICP and brain tissue PO2 monitoring were compared with historical controls matched for age, pathological features, admission GCS score, and Injury Severity Score who had undergone ICP monitoring alone. Therapy in both patient groups was aimed at maintaining an ICP less than 20 mm Hg and a CPP greater than 60 mm Hg. Among patients who...

Author-supplied keywords

  • brain tissue oxygenation
  • intracranial pressure
  • intracranial pressure monitoring
  • mortality rate
  • traumatic brain injury

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  • Michael F. Stiefel

  • Alejandro Spiotta

  • Vincent H. Gracias

  • Alicia M. Garuffe

  • Oscar Guillamondegui

  • Eileen Maloney-Wilensky

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