Exposure to alumina dust has been recently associated with impaired lung mechanics and inflammation. We aimed at evaluating if moderate exercise training prevents these outcomes. Twenty-three female BALB/c mice (25-30g) were randomly divided in two main groups: control (C) and exercise (E), which were submitted, or not, to 15min of swimming, 5 days/week during 4 weeks. Then, the animals were exposed for 1h to either saline solution (CS or ES) or to a suspension of 8mg/m3 of alumina dust (CA or EA). Twenty-four hours later pulmonary mechanics was determined by the end-inflation occlusion method. Left lungs were prepared for histology and right lungs for TGF-β determination. Static elastance increased after alumina dust exposure independently of swimming. In CA group the viscoelastic component of elastance, the viscoelastic/inhomogeneous pressure, the polymorphonuclear amount, the fraction area of alveolar collapse and TGF-β increased. Thus, exercise training may mitigate the pro-inflammatory response to inhaled aluminum refinery dust. © 2013 Elsevier B.V.
CITATION STYLE
Normando, V. M. F., Mazzoli-Rocha, F., Moreira, D. K. M., Barcellos, B. C., Picanço-Diniz, D. W., & Zin, W. A. (2013). Regular exercise training attenuates pulmonary inflammatory responses to inhaled alumina refinery dust in mice. Respiratory Physiology and Neurobiology, 186(1), 53–60. https://doi.org/10.1016/j.resp.2012.12.010
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