Regular exercise training attenuates pulmonary inflammatory responses to inhaled alumina refinery dust in mice

  • Normando V
  • Mazzoli-Rocha F
  • Moreira D
 et al. 
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Abstract

Exposure to alumina dust has been recently associated with impaired lung mechanics and inflammation. We aimed at evaluating if moderate exercise training prevents these outcomes. Twenty-three female BALB/c mice (25-30g) were randomly divided in two main groups: control (C) and exercise (E), which were submitted, or not, to 15min of swimming, 5 days/week during 4 weeks. Then, the animals were exposed for 1h to either saline solution (CS or ES) or to a suspension of 8mg/m3of alumina dust (CA or EA). Twenty-four hours later pulmonary mechanics was determined by the end-inflation occlusion method. Left lungs were prepared for histology and right lungs for TGF-β determination. Static elastance increased after alumina dust exposure independently of swimming. In CA group the viscoelastic component of elastance, the viscoelastic/inhomogeneous pressure, the polymorphonuclear amount, the fraction area of alveolar collapse and TGF-β increased. Thus, exercise training may mitigate the pro-inflammatory response to inhaled aluminum refinery dust. © 2013 Elsevier B.V.

Author-supplied keywords

  • Air pollution
  • Alumina
  • Inflammation
  • Lung mechanics
  • Particulate matter

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Authors

  • Valéria Marques Ferreira Normando

  • Flavia Mazzoli-Rocha

  • Dayse Kelly Molina Moreira

  • Bárbara Chaves Barcellos

  • Domingos Wanderley Picanço-Diniz

  • Walter Araújo Zin

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