Regulatory effects of osteoprotegerin on cellular and humoral immune responses.

  • Stolina M
  • Guo J
  • Faggioni R
 et al. 
  • 5


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


The interaction between receptor activator of nuclear factor-kappaB ligand (RANKL) and RANK has been reported to regulate immunity in addition to bone metabolism. The aim of this study was to determine if osteoprotegerin (OPG), an inhibitor of the RANKL-RANK interaction and possibly a new drug against osteoporosis, would adversely affect immunity. OPG was used to treat mice developing different models of cellular and humoral immune responses and also in vitro in T and B cell assays. In mice, OPG does not affect cell-mediated reactions such as contact hypersensitivity to the hapten oxazolone and liver damage, granuloma formation, and infectious load induced by mycobacterial infection. However, OPG increases humoral reactions such as the production of IgM, IgG, and IgE against the T cell dependent antigen keyhole limpet hemocyanin and the production of IgM against the T cell independent antigen Pneumovax. In vitro, OPG modestly co-stimulates T cells but does not affect the proliferation of B cells. OPG has modest immunoregulatory effects that seem to be confined to the humoral response to specific antigens.

Author-supplied keywords

  • Animals
  • Antibody Formation
  • B-Lymphocytes
  • Cell Division
  • Cellular
  • Cytoplasmic and Nuclear
  • Delayed
  • Female
  • Glycoproteins
  • Hemocyanin
  • Humans
  • Hypersensitivity
  • Immunity
  • Immunoglobulins
  • Inbred BALB C
  • Liver
  • Mice
  • Mycobacterium bovis
  • Osteoprotegerin
  • Oxazolone
  • Pneumococcal Vaccines
  • Receptors
  • T-Lymphocytes
  • Tumor Necrosis Factor
  • blood
  • cytology
  • drug effects
  • immunology
  • pathology

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Marina Stolina

  • Jane Guo

  • Raffaella Faggioni

  • Heather Brown

  • Giorgio Senaldi

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free