Remodeling of renal interstitial and tubular lesions in pancreas transplant recipients

  • Fioretto P
  • Sutherland D
  • Najafian B
 et al. 
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Abstract

Tubular atrophy and interstitial fibrosis, important in progression of renal diseases, including diabetic (D) and cyclosporine-induced (CSA) nephropathy, have been considered irreversible. Normoglycemia for 10 years following pancreas transplantation alone (PTA) reversed D glomerulopathy lesions. This study quantified tubular, interstitial, and arteriolar parameters in PTA recipients. Kidney function studies and biopsies were performed in eight non-uremic type I D patients (pts) at 5 and 10 years after PTA. Renal biopsies were analyzed by morphometric analysis. All pts were normoglycemic and insulin independent and received CSA during the study. Cortical interstitial volume fraction was increased at 5 years (0.31+/-0.07 vs normal 0.15+/-0.02, P

Author-supplied keywords

  • Diabetic nephropathy; cyclosporine nephrotoxicity
  • Interstitial fibrosis
  • Morphometric analysis
  • Pancreas transplantation
  • Tubular atrophy

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Authors

  • P. Fioretto

  • D. E R Sutherland

  • B. Najafian

  • M. Mauer

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