Skip to content
Journal article

Repopulation of cancer cells during therapy: an important cause of treatment failure

Kim J, Tannock I ...see all

Nature Reviews Cancer, vol. 5, issue 7 (2005) pp. 516-525

  • 174


    Mendeley users who have this article in their library.
  • 343


    Citations of this article.
  • N/A


    ScienceDirect users who have downloaded this article.
Sign in to save reference


Radiotherapy and chemotherapy are given in multiple doses, which are spaced out to allow the recovery of normal tissues between treatments. However, surviving cancer cells also proliferate during the intervals between treatments and this process of repopulation is an important cause of treatment failure. Strategies developed to overcome repopulation have improved clinical outcomes, and now new strategies to inhibit repopulation are emerging in parallel with advances in the understanding of underlying biological mechanisms.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Get full text


  • John J. Kim

  • Ian F. Tannock

Cite this document

Choose a citation style from the tabs below