Resveratrol sensitization of DU145 prostate cancer cells to ionizing radiation is associated to ceramide increase

  • Scarlatti F
  • Sala G
  • Ricci C
 et al. 
  • 24

    Readers

    Mendeley users who have this article in their library.
  • 66

    Citations

    Citations of this article.

Abstract

Radiotherapy is an established therapeutic modality for prostate cancer. Since it is well known that radiotherapy is limited due to its severe toxicity towards normal cells at high dose and minimal effect at low dose, the search for biological compounds that increase the sensitivity of tumors cells to radiation may improve the efficacy of therapy. Resveratrol, a natural antioxidant, was shown to inhibit carcinogenesis in animal models, and to block the process of tumor initiation and progression. The purpose of this study was to examine whether or not resveratrol can sensitize DU145, an androgen-independent human prostate cancer cell line, to ionizing radiation. We report here that DU145 cells are resistant to ionizing radiation-induced cell death, but pretreatment with resveratrol significantly enhances cell death. Resveratrol acts synergistically with ionizing radiation to inhibit cell survival in vitro. Resveratrol also potentiates ionizing radiation-induced ceramide accumulation, by promoting its de novo biosynthesis. This confirms ceramide as an effective mediator of the anticancer potential induced by resveratrol. © 2007 Elsevier Ireland Ltd. All rights reserved.

Author-supplied keywords

  • Radioresistance
  • Sphingolipid signaling
  • Synergism

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Francesca Scarlatti

  • Giusy Sala

  • Clara Ricci

  • Claudio Maioli

  • Franco Milani

  • Marco Minella

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free