A retrospective multicenter analysis of elderly Hodgkin lymphoma: outcomes and prognostic factors in the modern era.

  • Evens A
  • Helenowski I
  • Ramsdale E
 et al. 
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Abstract

We investigated a recent (1/99-12/09) cohort of 95 elderly Hodgkin lymphoma subjects. At diagnosis, median age was 67 years (60-89), while 61% had significant co-morbidity, 17% had a geriatric syndrome, 26% were unfit, and 13% had loss of activities of daily living (ADL). Response rate to therapy was 85%, while incidence of bleomycin lung toxicity was 32% (associated mortality rate: 25%). With 66-month median follow-up, 2-year and 5-year overall survival (OS) were 73% and 58%, respectively (advanced-stage: 63% and 46%, respectively). Most IPS factors were not prognostic on univariate analyses, while multivariate regression identified 2 risk factors associated with inferior OS: 1) Age >70 years (2.24 (95%CI 1.16-4.33), p=0.02) and 2) Loss of ADLs (2.71 (95%CI 1.07-6.84), p=0.04). Furthermore, a novel survival model based on number of risk factors (0, 1, or 2) showed differential 2-year OS 83%, 70%, 13%, respectively (p

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Authors

  • Andrew M Evens

  • Irene Helenowski

  • Erika Ramsdale

  • Chadi Nabhan

  • Reem Karmali

  • Britt Hanson

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