Loss of the lysosomal chloride transport protein ClC-7 leads to complex phenotypes in mice and man, including osteopetrosis, accumulation of lysosomal storage material, and neurodegeneration. Using novel tissue-specific ClC-7 knockout mice, we have shown that upon loss of ClC-7, lysosomal degradation of endocytosed protein is slowed down and accumulation of autophagosomes occurs. © 2010 Landes Bioscience.
CITATION STYLE
Wartosch, L., & Stauber, T. (2010). A role for chloride transport in lysosomal protein degradation. Autophagy, 6(1), 158–159. https://doi.org/10.4161/auto.6.1.10590
Mendeley helps you to discover research relevant for your work.