A role for peripheral blood fibrocytes in Lyme disease?

  • Grab D
  • Salim M
  • Chesney J
 et al. 
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It is proposed that peripheral blood fibrocytes will be a new and important player in the pathogenesis of Lyme disease. Peripheral blood fibrocytes are a circulating leukocyte subpopulation that: (a) express collagen; (b) are an abundant source of cytokines, chemoattractants and growth factors; and (c) are able to recruit and activate naive T-cells and memory T-cells. We predict that peripheral blood fibrocytes will represent a new and important antigen-presenting cell which will play an important role in directing the immune response from the pathogenic Th1 to the protective Th2 response cell in Borrelia infections. © 2002 Elsevier Science Ltd. All rights reserved.

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  • D. J. Grab

  • M. Salim

  • J. Chesney

  • R. Bucala

  • H. N. Lanners

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