It is proposed that peripheral blood fibrocytes will be a new and important player in the pathogenesis of Lyme disease. Peripheral blood fibrocytes are a circulating leukocyte subpopulation that: (a) express collagen; (b) are an abundant source of cytokines, chemoattractants and growth factors; and (c) are able to recruit and activate naive T-cells and memory T-cells. We predict that peripheral blood fibrocytes will represent a new and important antigen-presenting cell which will play an important role in directing the immune response from the pathogenic Th1 to the protective Th2 response cell in Borrelia infections. © 2002 Elsevier Science Ltd. All rights reserved.
CITATION STYLE
Grab, D. J., Salim, M., Chesney, J., Bucala, R., & Lanners, H. N. (2002). A role for peripheral blood fibrocytes in Lyme disease? Medical Hypotheses, 59(1), 1–10. https://doi.org/10.1016/S0306-9877(02)00189-5
Mendeley helps you to discover research relevant for your work.